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Cancel free on most hotels. Compare 158 hotels in Key West using 42464 real guest reviews. Earn free nights and get our Price Guarantee - booking has never been easier on ! Key West is the southernmost point of the US and the westernmost island of the Florida Keys. The city occupies an entire island along with portions of surrounding islands; its land area totals around 6 square miles. US Route 1 and Florida State Road A1A both end in Key West. Key West offers a variety of water activities,